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KMID : 1038820190220040330
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Pediatric Gastroenterology, Hepatology & Nutrition
2019 Volume.22 No. 4 p.330 ~ p.340
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The Role of Two Human Milk Oligosaccharides, 2′-Fucosyllactose and Lacto-N-Neotetraose, in Infant Nutrition
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Hegar Badriul
Wibowo Yulianti
Basrowi Ray Wagiu
Ranuh Reza Gunadi
Sudarmo Subianto Marto
Munasir Zakiudin
Atthiyah Alpha Fardah
Widodo Ariani Dewi
Supriatmo
Kadim Muzal
Suryawan Ahmad
Diana Ninung Rose
Manoppo Christy
Vandenplas Yvan
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Abstract
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Human breast milk contains numerous biomolecules. Human milk oligosaccharides (HMOs) are the third most abundant component of breast milk, after lactose and lipids. Amongst the synthetized HMOs, 2′-fucosyllactose (2′-FL) and lacto-N-neotetraose (LNnT) are widely studied and are considered safe for infant nutrition. Several studies have reported the health benefits of HMOs, which include modulation of the intestinal microbiota, anti-adhesive effect against pathogens, modulation of the intestinal epithelial cell response, and development of the immune system. The amount and diversity of HMOs are determined by the genetic background of the mothers (HMO secretors or non-secretors). The non-secretor mothers secrete lower HMOs than secretor mothers. The breastfed infants of secretor mothers gain more health benefit than those of non-secretor mothers. In conclusion, supplementation of infant formula with 2′-FL and LNnT is a promising innovation for infant nutrition.
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KEYWORD
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Human milk, Oligosaccharide, 2′-fucosyllactose, Lacto-N-neotetraose, Infant, Breast feeding
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